Providence/Boston Center for Aids Research (CFAR)

Substance Use Research Core

The Substance Use Research Core (SURC) supports the development of basic, clinical, and translational research that addresses the impact of substance use (SU) on the HIV epidemic.

The Substance Use Research Core (SURC) offers services and expertise on the methods needed to conduct effective Substance Use (SU)/HIV research.  Services will be directed at: 1) hypothesis generation, 2) assessment, 3) intervention development, and 4) ethical considerations of SU research.  The SURC offers expertise in innovative methods for assessing and analyzing SU, and developing and implementing interventions to address alcohol, tobacco, and other drug use.

  • Expertise in developing research projects that address gaps in SU/HIV priority issues both domestically and globally.
  • Advice and training on the most appropriate methods for assessing SU.
  • Advice and training on incorporating effective and up-to-date SU interventions.
  • Guidance on addressing ethical issues with SU research including input on IRB protocols and human subject sections of grant applications and access to group trainings.
  • Identifying appropriate existing datasets for secondary analyses by investigators examining SU and HIV.

Bendiks S, Cheng DM, Blokhina E, Vetrova M, Verbitskaya E, Gnatienko N, Bryant K, Krupitsky E, Samet JH, Tsui JI. Pilot study of tolerability and safety of opioid receptor antagonists as novel therapies for chronic pain among persons living with HIV with past year heavy drinking: a randomized controlled trial. AIDS Care. 2021 Mar 7:1-10. PMCID: in process.

Bhatraju E, Liebschutz JM, Lodi S, Forman LS, Lira MC, Kim TW, Colasanti J, Del Rio C, Samet JH, Tsui JI. Post-traumatic stress disorder and risky opioid use among persons living with HIV and chronic pain. AIDS Care. 2021 Feb 4:1-8. PMCID: in process.

Chavez K, Palfai TP, Cheng DM, Blokhina, E, Gnatienko N, Quinn EK, Krupitsky E, Samet JH. Hazardous alcohol use, impulsivity, and HIV-risk behavior among HIV-positive Russian patients with a history of injection drug use. Am J Addict. 2021;30(2):164-172. PMCID: in process.

Corcorran MA, Ludwig-Baron N, Cheng DM, Lioznov D, Gnatienko N, Patts G, So-Armah K, Blokhina E, Bendiks S, Krupitsky E, Samet JH, Tsui JI. The hepatitis C continuum of care among HIV-positive persons with heavy alcohol use in St. Petersburg, Russia. AIDS Behav. 2021 Mar 17. PMCID: in process.

Freiberg MS, Cheng DM, Gnatienko N, Blokhina E, Coleman SM, Doyle MF, Yaroslavtseva T, Bridden C, So-Armah K, Tracy R, Bryant K, Lioznov D, Krupitsky E, Samet JH. Effect of zinc supplementation vs placebo on mortality risk and HIV disease progression among HIV-positive adults with heavy alcohol use: a randomized clinical trial. JAMA Netw Open. 2020 May 1;3(5):e204330. PMCID: PMC7210486.

Ganguly AP, Lira MC, Lodi S, Forman LS, Colasanti JA, Williams EC, Liebschutz JM, Del Rio C, Samet JH, Tsui JI. Race and satisfaction with pain management among patients with HIV receiving long-term opioid therapy. Drug Alcohol Depend. 2021 Mar 18:108662. PMCID: in process.

Kimmel SD, Walley AY, Lodi S, Forman LS, Liebschutz JM, Lira MC, Kim TW, Del Rio C, Samet JH, Tsui JI. Naloxone receipt and overdose prevention care among people with HIV on chronic opioid therapy. AIDS. 2021 Mar 15;35(4):697-700. PMCID: PMC7904637.

Lee JO, Yoon Y, Idrisov B, Kiriazova T, Makarenko O, Sereda Y, Bendiks S, Cody K, Schoenberger SF, Nurius PS, Halim N, Flanigan T, Samet JH, Liebschutz J, Lunze K. Violence, HIV risks, and polysubstance use among HIV-positive people who inject drugs in Ukraine [published online ahead of print, 2021 Jan 1]. AIDS Behav. 2021;10.1007/s10461-020-03142-3. PMCID: in process.

Lunze K, Kiriazova T, Blokhina E, Bushara N, Bridden C, Gnatienko N, Bendiks S, Quinn E, Krupitsky E, Raj A, Samet JH. Linking HIV-positive people in addiction care to HIV services in St. Petersburg, Russia - Mixed-methods implementation study of strengths-based case management. Glob Public Health. 2020 Oct 22:1-13. PMCID: in process.

Lodi S, Freiberg M, Gnatienko N, Blokhina E, Yaroslavtseva T, Krupitsky E, Murray E, Samet JH, Cheng DM. Per-protocol analysis of the ZINC trial for HIV disease among alcohol users. Trials. 2021 Mar 23;22(1):226. PMCID: PMC7989012

Motavalli D, Taylor JL, Childs E, Valente PK, Salhaney P, Olson J, Biancarelli DL, Edeza A, Earlywine JJ, Marshall BDL, Drainoni ML, Mimiaga MJ, Biello KB, Bazzi AR. "Health is on the back burner:" Multilevel barriers and facilitators to primary care among people who inject drugs. J Gen Intern Med. 2021 Jan;36(1):129-137. PMCID: PMC7858998.

Ngo B, Liebschutz JM, Cheng DM, Colasanti JA, Merlin JS, Armstrong WS, Forman LS, Lira MC, Samet JH, Del Rio C, Tsui JI. Hazardous alcohol use is associated with greater pain interference and prescription opioid misuse among persons living with HIV and chronic pain. BMC Public Health. 2021 Dec;21(1):1-9. PMCID: PMC7986380.

Restar AJ, Jin H, Ogunbajo A, Adia A, Surace A, Hernandez L, Cu-Uvin S, Operario D. Differences in HIV risk and healthcare engagement factors in Filipinx transgender women and cisgender men who have sex with men who reported being HIV negative, HIV positive or HIV unknown. J Int AIDS Soc. 2020;23(8):e25582. PMCID: PMC7448155.

Tindle HA, Freiberg MS, Gnatienko N, Blokhina E, Cheng DM, Yaroslavtseva T, Bendiks S, Winter M, Krupitsky E, Samet JH. Design of a randomized controlled trial of smoking cessation medications for alcohol reduction among HIV-positive heavy drinkers and daily smokers in St. Petersburg, Russia. Contemp Clin Trials Commun. 2020 Jul 16;19:100625. PMCID: PMC7889999.

Samet JH, Tsui JI, Cheng DM, Liebschutz JM, Lira MC, Walley AY, Colasanti JA, Forman LS, Root C, Shanahan CW, Sullivan MM, Bridden CL, Abrams C, Harris C, Outlaw K, Armstrong WS, Del Rio C. Improving the delivery of chronic opioid therapy among people living with HIV: a cluster randomized clinical trial. Clin Infect Dis. 2020 Jul 22:ciaa1025. PMCID: in process.

Sereda Y, Kiriazova T, Makarenko O, Carroll JJ, Rybak N, Chybisov A, Bendiks S, Idrisov B, Dutta A, Gillani FS, Samet JH, Flanigan T, Lunze K. Stigma and quality of co-located care for HIV-positive people in addiction treatment in Ukraine: a cross-sectional study. J Int AIDS Soc. 2020;23(5):e25492. PMCID: PMC7201176.

Serota DP, Capozzi C, Lodi S, Colasanti JA, Forman LS, Tsui JI, Walley AY, Lira MC, Samet J, Del Rio C, Merlin JS. Predictors of pain-related functional impairment among people living with HIV on long-term opioid therapy. AIDS Care. 2021;33(4):507-515. PMCID: PMC7541400.

Vetrova MV, Cheng DM, Bendiks S, Gnatienko N, Lloyd-Travaglini C, Jiang W, Luoma J, Blokhina E, Krupitsky E, Lioznov D, Ekstrand ML, Raj A, Samet JH, Lunze K. HIV and substance use stigma, intersectional stigma and healthcare among HIV-positive PWID in Russia. AIDS Behav. 2021 Jan 28. PMCID: in process.

Wagman JA, Wynn A, Matsuzaki M, Gnatienko N, Metsch LR, Del Rio C, Feaster DJ, Nance RM, Whitney BM, Delaney JAC, Kahana SY, Crane HM, Chandler RK, Elliott JC, Altice F, Lucas GM, Mehta SH, Hirsch-Moverman Y, El-Sadr WM, Vu Q, Nguyen Thanh B, Springer SA, Tsui JI, Samet JH. Hazardous alcohol use, antiretroviral therapy receipt, and viral suppression in people living with HIV who inject drugs in the United States, India, Russia, and Vietnam. AIDS. 2020 Dec 1;34(15):2285-2294. PMCID: PMC7951611.

Wray TB, Monti PM, Kahler CW, Guigayoma JP. Using ecological momentary assessment (EMA) to explore mechanisms of alcohol-involved HIV risk behavior among men who have sex with men (MSM). Addiction. 2020; 115(12):2293-2302. PMCID: PMC7554063.